Table S5. KEGG pathway analysis of the differentially expressed genes in the Race1-LN vs. Race1-CK group class_A class_B Term Database ID Input number Background number P-Value Corrected P-Value Input Hyperlink Metabolism Carbohydrate metabolism Pentose and glucuronate interconversions KEGG PATHWAY ko00040 7 24 1.32E-05 0.001082416 A04777|A02053|A09657|A10597|A02403|A00319|A02404 http://www.genome.jp/kegg-bin/show_pathway?ko00040/K00065%09red/K00008%09red/K00128%09red/K18106%09red/K01213%09red/K05351%09red/K01728%09red Metabolism Amino acid metabolism Tryptophan metabolism KEGG PATHWAY ko00380 7 44 0.000373319 0.01530606 A08690|A07273|A00491|A00426|A11557|A00319|A10358 http://www.genome.jp/kegg-bin/show_pathway?ko00380/K03781%09red/K01556%09red/K03782%09red/K01426%09red/K00128%09red Metabolism Carbohydrate metabolism Starch and sucrose metabolism KEGG PATHWAY ko00500 7 60 0.001970352 0.053856284 A10872|A08882|A09657|A12212|A09232|A10282|A12007 http://www.genome.jp/kegg-bin/show_pathway?ko00500/K01179%09red/K01213%09red/K01182%09red/K01176%09red Metabolism Carbohydrate metabolism Glyoxylate and dicarboxylate metabolism KEGG PATHWAY ko00630 4 33 0.016809949 0.274631607 A07273|A00900|A10358|A08890 http://www.genome.jp/kegg-bin/show_pathway?ko00630/K03781%09red/K01637%09red/K00122%09red Metabolism Carbohydrate metabolism Galactose metabolism KEGG PATHWAY ko00052 4 33 0.016809949 0.274631607 A00884|A11061|A12212|A10872 http://www.genome.jp/kegg-bin/show_pathway?ko00052/K01182%09red/K04618%09red Metabolism Amino acid metabolism Arginine and proline metabolism KEGG PATHWAY ko00330 4 35 0.020094996 0.274631607 A00319|A04448|A08690|A11557 http://www.genome.jp/kegg-bin/show_pathway?ko00330/K00128%09red/K01426%09red/K01480%09red Metabolism Amino acid metabolism "Valine, leucine and isoleucine biosynthesis" KEGG PATHWAY ko00290 3 22 0.028728235 0.336530752 A10413|A10441|A03630 http://www.genome.jp/kegg-bin/show_pathway?ko00290/K01687%09red/K01649%09red/K17989%09red Organismal Systems Digestive system Carbohydrate digestion and absorption KEGG PATHWAY ko04973 2 10 0.040124818 0.411279388 A12007|A08882 http://www.genome.jp/kegg-bin/show_pathway?ko04973/K01176%09red Metabolism Metabolism of cofactors and vitamins Biotin metabolism KEGG PATHWAY ko00780 2 13 0.060583903 0.478153271 A00682|A01230 http://www.genome.jp/kegg-bin/show_pathway?ko00780/K00652%09red/K00059%09red Metabolism Amino acid metabolism Phenylalanine metabolism KEGG PATHWAY ko00360 3 32 0.067445952 0.478153271 A00491|A08690|A11557 http://www.genome.jp/kegg-bin/show_pathway?ko00360/K03782%09red/K01426%09red Metabolism Xenobiotics biodegradation and metabolism Styrene degradation KEGG PATHWAY ko00643 2 15 0.075797839 0.478153271 A08690|A11557 http://www.genome.jp/kegg-bin/show_pathway?ko00643/K01426%09red Environmental Information Processing Signal transduction FoxO signaling pathway KEGG PATHWAY ko04068 2 17 0.092072926 0.478153271 A07273|A10358 http://www.genome.jp/kegg-bin/show_pathway?ko04068/K03781%09red Metabolism Xenobiotics biodegradation and metabolism Chloroalkane and chloroalkene degradation KEGG PATHWAY ko00625 2 17 0.092072926 0.478153271 A11089|A00319 http://www.genome.jp/kegg-bin/show_pathway?ko00625/K00128%09red/K13953%09red Metabolism Carbohydrate metabolism Pyruvate metabolism KEGG PATHWAY ko00620 3 39 0.103563333 0.478153271 A10444|A00319|A03630 http://www.genome.jp/kegg-bin/show_pathway?ko00620/K00128%09red/K01649%09red/K00101%09red Metabolism Global and overview maps Carbon metabolism KEGG PATHWAY ko01200 6 114 0.104596854 0.478153271 A10441|A06884|A07273|A08890|A00900|A10358 http://www.genome.jp/kegg-bin/show_pathway?ko01200/K03781%09red/K01637%09red/K17100%09red/K17989%09red/K00122%09red Metabolism Global and overview maps 2-Oxocarboxylic acid metabolism KEGG PATHWAY ko01210 3 43 0.126994095 0.478153271 A04767|A10413|A03630 http://www.genome.jp/kegg-bin/show_pathway?ko01210/K01687%09red/K01649%09red/K05824%09red Metabolism Metabolism of other amino acids beta-Alanine metabolism KEGG PATHWAY ko00410 2 22 0.136424011 0.478153271 A10029|A00319 http://www.genome.jp/kegg-bin/show_pathway?ko00410/K00128%09red/K01464%09red Organismal Systems Aging Longevity regulating pathway KEGG PATHWAY ko04211 2 22 0.136424011 0.478153271 A07273|A10358 http://www.genome.jp/kegg-bin/show_pathway?ko04211/K03781%09red Metabolism Metabolism of cofactors and vitamins Pantothenate and CoA biosynthesis KEGG PATHWAY ko00770 2 24 0.155283517 0.478153271 A10029|A10413 http://www.genome.jp/kegg-bin/show_pathway?ko00770/K01687%09red/K01464%09red Metabolism Xenobiotics biodegradation and metabolism Aminobenzoate degradation KEGG PATHWAY ko00627 2 25 0.164894301 0.478153271 A08690|A11557 http://www.genome.jp/kegg-bin/show_pathway?ko00627/K01426%09red Metabolism Xenobiotics biodegradation and metabolism Naphthalene degradation KEGG PATHWAY ko00626 2 25 0.164894301 0.478153271 A11089|A11484 http://www.genome.jp/kegg-bin/show_pathway?ko00626/K13953%09red/K00480%09red Metabolism Xenobiotics biodegradation and metabolism Drug metabolism - cytochrome P450 KEGG PATHWAY ko00982 2 26 0.174608165 0.478153271 A03113|A11089 http://www.genome.jp/kegg-bin/show_pathway?ko00982/K13953%09red/K00799%09red Metabolism Metabolism of terpenoids and polyketides Limonene and pinene degradation KEGG PATHWAY ko00903 1 6 0.174934124 0.478153271 A00319 http://www.genome.jp/kegg-bin/show_pathway?ko00903/K00128%09red Organismal Systems Environmental adaptation Plant-pathogen interaction KEGG PATHWAY ko04626 1 6 0.174934124 0.478153271 A08071 http://www.genome.jp/kegg-bin/show_pathway?ko04626/K13447%09red Metabolism Xenobiotics biodegradation and metabolism Drug metabolism - other enzymes KEGG PATHWAY ko00983 1 6 0.174934124 0.478153271 A10029 http://www.genome.jp/kegg-bin/show_pathway?ko00983/K01464%09red Metabolism Metabolism of other amino acids Taurine and hypotaurine metabolism KEGG PATHWAY ko00430 1 6 0.174934124 0.478153271 A11724 http://www.genome.jp/kegg-bin/show_pathway?ko00430/K15371%09red Metabolism Xenobiotics biodegradation and metabolism Metabolism of xenobiotics by cytochrome P450 KEGG PATHWAY ko00980 2 27 0.18441267 0.487801255 A03113|A11089 http://www.genome.jp/kegg-bin/show_pathway?ko00980/K13953%09red/K00799%09red Metabolism Energy metabolism Methane metabolism KEGG PATHWAY ko00680 2 28 0.194295961 0.4978834 A00900|A06884 http://www.genome.jp/kegg-bin/show_pathway?ko00680/K17100%09red/K00122%09red Cellular Processes Transport and catabolism Lysosome KEGG PATHWAY ko04142 2 29 0.204246746 0.507522218 A04287|A09856 http://www.genome.jp/kegg-bin/show_pathway?ko04142/K01279%09red Metabolism Lipid metabolism Glycerolipid metabolism KEGG PATHWAY ko00561 2 30 0.214254276 0.516730902 A02400|A00319 http://www.genome.jp/kegg-bin/show_pathway?ko00561/K00128%09red/K18097%09red Metabolism Lipid metabolism Fatty acid degradation KEGG PATHWAY ko00071 2 32 0.234399156 0.54284457 A11089|A00319 http://www.genome.jp/kegg-bin/show_pathway?ko00071/K00128%09red/K13953%09red Metabolism Biosynthesis of other secondary metabolites Aflatoxin biosynthesis KEGG PATHWAY ko00254 1 9 0.240292835 0.54284457 A11227 http://www.genome.jp/kegg-bin/show_pathway?ko00254/K17644%09red Metabolism Biosynthesis of other secondary metabolites Betalain biosynthesis KEGG PATHWAY ko00965 1 10 0.260919352 0.54284457 A02911 http://www.genome.jp/kegg-bin/show_pathway?ko00965/K00505%09red Metabolism Metabolism of cofactors and vitamins Retinol metabolism KEGG PATHWAY ko00830 1 10 0.260919352 0.54284457 A11089 http://www.genome.jp/kegg-bin/show_pathway?ko00830/K13953%09red Metabolism Carbohydrate metabolism Ascorbate and aldarate metabolism KEGG PATHWAY ko00053 1 10 0.260919352 0.54284457 A00319 http://www.genome.jp/kegg-bin/show_pathway?ko00053/K00128%09red Metabolism Global and overview maps Degradation of aromatic compounds KEGG PATHWAY ko01220 2 35 0.264802229 0.54284457 A11089|A11484 http://www.genome.jp/kegg-bin/show_pathway?ko01220/K13953%09red/K00480%09red Metabolism Metabolism of cofactors and vitamins Ubiquinone and other terpenoid-quinone biosynthesis KEGG PATHWAY ko00130 1 11 0.280991582 0.561892551 A07263 http://www.genome.jp/kegg-bin/show_pathway?ko00130/K03809%09red Cellular Processes Transport and catabolism Peroxisome KEGG PATHWAY ko04146 3 69 0.30915757 0.561892551 A07273|A01284|A10358 http://www.genome.jp/kegg-bin/show_pathway?ko04146/K03781%09red/K11187%09red Cellular Processes Cellular community - prokaryotes Quorum sensing KEGG PATHWAY ko02024 1 13 0.31953176 0.561892551 A10597 http://www.genome.jp/kegg-bin/show_pathway?ko02024/K01728%09red Metabolism Metabolism of cofactors and vitamins One carbon pool by folate KEGG PATHWAY ko00670 1 13 0.31953176 0.561892551 A07394 http://www.genome.jp/kegg-bin/show_pathway?ko00670/K00604%09red Metabolism Amino acid metabolism Lysine biosynthesis KEGG PATHWAY ko00300 1 13 0.31953176 0.561892551 A04767 http://www.genome.jp/kegg-bin/show_pathway?ko00300/K05824%09red Metabolism Lipid metabolism Fatty acid biosynthesis KEGG PATHWAY ko00061 1 14 0.338028035 0.561892551 A01230 http://www.genome.jp/kegg-bin/show_pathway?ko00061/K00059%09red Metabolism Lipid metabolism Glycerophospholipid metabolism KEGG PATHWAY ko00564 2 44 0.355423313 0.561892551 A10994|A09690 http://www.genome.jp/kegg-bin/show_pathway?ko00564/K13333%09red/K01613%09red Metabolism Carbohydrate metabolism Glycolysis / Gluconeogenesis KEGG PATHWAY ko00010 2 44 0.355423313 0.561892551 A11089|A00319 http://www.genome.jp/kegg-bin/show_pathway?ko00010/K00128%09red/K13953%09red Metabolism Amino acid metabolism Tyrosine metabolism KEGG PATHWAY ko00350 2 44 0.355423313 0.561892551 A11089|A02911 http://www.genome.jp/kegg-bin/show_pathway?ko00350/K13953%09red/K00505%09red Metabolism Biosynthesis of other secondary metabolites Phenylpropanoid biosynthesis KEGG PATHWAY ko00940 1 16 0.373541004 0.561892551 A00491 http://www.genome.jp/kegg-bin/show_pathway?ko00940/K03782%09red Organismal Systems Endocrine system Melanogenesis KEGG PATHWAY ko04916 1 16 0.373541004 0.561892551 A02911 http://www.genome.jp/kegg-bin/show_pathway?ko04916/K00505%09red Metabolism Metabolism of cofactors and vitamins Riboflavin metabolism KEGG PATHWAY ko00740 1 16 0.373541004 0.561892551 A02911 http://www.genome.jp/kegg-bin/show_pathway?ko00740/K00505%09red Metabolism Amino acid metabolism Arginine biosynthesis KEGG PATHWAY ko00220 1 17 0.390583847 0.561892551 A11724 http://www.genome.jp/kegg-bin/show_pathway?ko00220/K15371%09red Metabolism Xenobiotics biodegradation and metabolism Dioxin degradation KEGG PATHWAY ko00621 1 17 0.390583847 0.561892551 A11484 http://www.genome.jp/kegg-bin/show_pathway?ko00621/K00480%09red Metabolism Energy metabolism Nitrogen metabolism KEGG PATHWAY ko00910 1 17 0.390583847 0.561892551 A11724 http://www.genome.jp/kegg-bin/show_pathway?ko00910/K15371%09red Metabolism Xenobiotics biodegradation and metabolism Polycyclic aromatic hydrocarbon degradation KEGG PATHWAY ko00624 1 17 0.390583847 0.561892551 A11484 http://www.genome.jp/kegg-bin/show_pathway?ko00624/K00480%09red Metabolism Carbohydrate metabolism Propanoate metabolism KEGG PATHWAY ko00640 1 20 0.439007552 0.599976988 A06768 http://www.genome.jp/kegg-bin/show_pathway?ko00640/K18369%09red Metabolism Glycan biosynthesis and metabolism Glycosylphosphatidylinositol(GPI)-anchor biosynthesis KEGG PATHWAY ko00563 1 20 0.439007552 0.599976988 A07073 http://www.genome.jp/kegg-bin/show_pathway?ko00563/K05285%09red Metabolism Lipid metabolism Biosynthesis of unsaturated fatty acids KEGG PATHWAY ko01040 1 20 0.439007552 0.599976988 A01230 http://www.genome.jp/kegg-bin/show_pathway?ko01040/K00059%09red Metabolism Biosynthesis of other secondary metabolites Isoquinoline alkaloid biosynthesis KEGG PATHWAY ko00950 1 21 0.454286877 0.60083103 A02911 http://www.genome.jp/kegg-bin/show_pathway?ko00950/K00505%09red Metabolism Amino acid metabolism Histidine metabolism KEGG PATHWAY ko00340 1 21 0.454286877 0.60083103 A00319 http://www.genome.jp/kegg-bin/show_pathway?ko00340/K00128%09red Metabolism Global and overview maps Biosynthesis of amino acids KEGG PATHWAY ko01230 4 125 0.465099557 0.605367678 A04767|A10413|A10441|A03630 http://www.genome.jp/kegg-bin/show_pathway?ko01230/K01687%09red/K01649%09red/K05824%09red/K17989%09red Metabolism Nucleotide metabolism Pyrimidine metabolism KEGG PATHWAY ko00240 2 63 0.530348102 0.658065611 A10029|A06920 http://www.genome.jp/kegg-bin/show_pathway?ko00240/K00762%09red/K01464%09red Metabolism Amino acid metabolism "Alanine, aspartate and glutamate metabolism" KEGG PATHWAY ko00250 1 27 0.537687755 0.658065611 A11724 http://www.genome.jp/kegg-bin/show_pathway?ko00250/K15371%09red Metabolism Amino acid metabolism Lysine degradation KEGG PATHWAY ko00310 1 30 0.574525358 0.673015419 A00319 http://www.genome.jp/kegg-bin/show_pathway?ko00310/K00128%09red Metabolism Metabolism of other amino acids Glutathione metabolism KEGG PATHWAY ko00480 1 30 0.574525358 0.673015419 A03113 http://www.genome.jp/kegg-bin/show_pathway?ko00480/K00799%09red Metabolism Carbohydrate metabolism Fructose and mannose metabolism KEGG PATHWAY ko00051 1 33 0.608456141 0.702723993 A02403 http://www.genome.jp/kegg-bin/show_pathway?ko00051/K00008%09red Genetic Information Processing Translation Aminoacyl-tRNA biosynthesis KEGG PATHWAY ko00970 1 35 0.629574662 0.717015587 A07394 http://www.genome.jp/kegg-bin/show_pathway?ko00970/K00604%09red Metabolism Global and overview maps Fatty acid metabolism KEGG PATHWAY ko01212 1 36 0.639707229 0.718575244 A01230 http://www.genome.jp/kegg-bin/show_pathway?ko01212/K00059%09red Metabolism Amino acid metabolism "Valine, leucine and isoleucine degradation" KEGG PATHWAY ko00280 1 38 0.659156735 0.730416923 A00319 http://www.genome.jp/kegg-bin/show_pathway?ko00280/K00128%09red Metabolism Amino acid metabolism Cysteine and methionine metabolism KEGG PATHWAY ko00270 1 42 0.69499232 0.75985827 A10441 http://www.genome.jp/kegg-bin/show_pathway?ko00270/K17989%09red Metabolism Amino acid metabolism "Glycine, serine and threonine metabolism" KEGG PATHWAY ko00260 1 53 0.77543178 0.804878557 A10441 http://www.genome.jp/kegg-bin/show_pathway?ko00260/K17989%09red Metabolism Energy metabolism Oxidative phosphorylation KEGG PATHWAY ko00190 1 69 0.856391507 0.866964241 A10299 http://www.genome.jp/kegg-bin/show_pathway?ko00190/K02128%09red Genetic Information Processing Translation RNA transport KEGG PATHWAY ko03013 1 86 0.91090154 0.91090154 A10290 http://www.genome.jp/kegg-bin/show_pathway?ko03013/K12160%09red